54
In band
ETF profile
SPDR Biotech ETF holds 166 positions. The top 10 make up 17.8% of the fund, led by MRNA (2.3%), TWST (2.0%) and NTRA (1.9%). Healthcare is 96.5% of assets. Net assets are $10.4B and the expense ratio is 0.35%. The fund launched on 31 January 2006.
Net assets$10.40B
Expense ratio0.35%
Dividend yield-0.14%
Portfolio turnover71.0%
Inception31 January 2006
Sector allocation
Healthcare 96.5%
Top holdings
On daily RSI (14), 2 of the 4 of XBI's top 10 holdings tracked here are overbought (AMGN, ABBV).
| Symbol | Name | Weight | RSI |
|---|---|---|---|
| MRNA | MODERNA INC | 2.27% | 57 |
| TWST | TWIST BIOSCIENCE CORP | 1.99% | |
| NTRA | NATERA INC | 1.85% | 57 |
| HALO | HALOZYME THERAPEUTICS INC | 1.74% | |
| BIIB | BIOGEN INC | 1.67% | |
| AMGN | AMGEN INC | 1.66% | 71 |
| UTHR | UNITED THERAPEUTICS CORP | 1.66% | |
| SYRE | SPYRE THERAPEUTICS INC | 1.65% | |
| ABBV | ABBVIE INC | 1.64% | 73 |
| EXEL | EXELIXIS INC | 1.63% |
RSI alerts for XBI
An email when XBI closes below RSI 30 or above 70. Nothing else.
Add alertData last updated 31 October 2026 at 8:25 PM EDT